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1

Oxidant-Antioxidant Balance And Peripheral Vascular Function

Hogwood, Austin C., Weggen, Jennifer, Fralin, Carson, Lee, David, Scott, Matthew, Garten, Ryan S.

Journal:

Medicine & Science in Sports & Exercise

Year:

2018

Language:

english

File:

PDF, 110 KB

english, 2018

2

Characterization of Neural Cell Lines Derived from SV40 Large T-Induced Primitive Neuroectodermal Tumors

Sascha Weggen, Thomas A. Bayer, Anke Koch, Holger Salewski, Karl-Heinz Scheidtmann, Torsten Pietsch, Otmar D. Wiestler

Journal:

Brain Pathology

Year:

1997

Language:

english

File:

PDF, 4.11 MB

english, 1997

3

Ullmann's Encyclopedia of Industrial Chemistry || Oil and Gas

Year:

2000

Language:

english

File:

PDF, 2.34 MB

english, 2000

4

Aerobic Training Status Does Not Attenuate Prolonged Sitting-Induced Lower Limb Vascular Dysfunction

Garten, Ryan S., Hogwood, Austin C., Weggen, Jennifer, Fralin, R. Carson, LaRosa, Kathryn, Lee, David, Michael, Austin, Scott, Matthew

Journal:

Applied Physiology Nutrition and Metabolism

Year:

2018

Language:

english

File:

PDF, 548 KB

english, 2018

5

Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies

Anke Diehlmann, Nobuo Ida, Sascha Weggen, Jürgen Grünberg, Christian Haass, Colin L. Masters, Thomas A. Bayer, Konrad Beyreuther

Journal:

Journal of Neuroscience Research

Year:

1999

Language:

english

File:

PDF, 707 KB

english, 1999

6

Curcumin-Derived Pyrazoles and Isoxazoles: Swiss Army Knives or Blunt Tools for Alzheimer's Disease?

Rajeshwar Narlawar, Marcus Pickhardt, Stefanie Leuchtenberger, Karlheinz Baumann, Sabine Krause, Thomas Dyrks, Sascha Weggen, Eckhard Mandelkow, Boris Schmidt

Journal:

Year:

2008

Language:

english

File:

PDF, 324 KB

english, 2008

7

Nonsteroidal antiinflammatory drugs as therapeutic agents for Alzheimer's disease

Todd E. Golde, Jason L. Eriksen, Sascha Weggen, Sarah A. Sagi, Edward H. Koo

Journal:

Drug Development Research

Year:

2002

Language:

english

File:

PDF, 78 KB

english, 2002

8

Polygenetic lateritic iron ores on BIF's in Minas Gerais/Brazil

J. Weggen, I. Valeton

Journal:

International Journal of Earth Sciences

Year:

1990

Language:

english

File:

PDF, 1.48 MB

english, 1990

9

Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis

Sara M. Reekmans, Thorsten Pflanzner, Philip L. S. M. Gordts, Simone Isbert, Pascale Zimmermann, Wim Annaert, Sascha Weggen, Anton J. M. Roebroek, Claus U. Pietrzik

Journal:

Cellular and Molecular Life Sciences

Year:

2010

Language:

english

File:

PDF, 418 KB

english, 2010

10

Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer’s disease

Thomas A. Bayer, Krzysztof Paliga, Sascha Weggen, O. D. Wiestler, Konrad Beyreuther, Gerd Multhaup

Journal:

Acta Neuropathologica

Year:

1997

Language:

english

File:

PDF, 399 KB

english, 1997

11

Reverse relationship between β-amyloid precursor protein and β-amyloid peptide plaques in Down’s syndrome versus sporadic/familial Alzheimer’s disease

Rupert Egensperger, Sascha Weggen, Nobua Ida, Gerd Multhaup, Ralf Schnabel, Konrad Beyreuther, T. A. Bayer

Journal:

Acta Neuropathologica

Year:

1999

Language:

english

File:

PDF, 260 KB

english, 1999

12

Migratory potential of transplantable neural tumor cell lines

T. A. Bayer, Michael Thier, Elke Roeb, Bettina Breuer, Sascha Weggen, Otmar D. Wiestler, Joachim Weis

Journal:

Acta Neuropathologica

Year:

1999

Language:

english

File:

PDF, 484 KB

english, 1999

13

Validation of computational fluid dynamics (CFD) tools for the development of a helium-cooled divertor

R. Kruessmann, G. Messemer, P. Norajitra, J. Weggen, K. Zinn

Journal:

Fusion Engineering and Design

Year:

2007

Language:

english

File:

PDF, 396 KB

english, 2007

14

Inhibitors of Rho-kinase modulate amyloid-β (Aβ) secretion but lack selectivity for Aβ42

Stefanie Leuchtenberger, Markus P. Kummer, Thomas Kukar, Eva Czirr, Nicole Teusch, Sarah A. Sagi, Rebecca Berdeaux, Claus U. Pietrzik, Thomas B. Ladd, Todd E. Golde, Edward H. Koo, Sascha Weggen

Journal:

Journal of Neurochemistry

Year:

2006

Language:

english

File:

PDF, 642 KB

english, 2006

15

α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation

Sebastian Jäger, Stefanie Leuchtenberger, Anne Martin, Eva Czirr, Johanna Wesselowski, Marco Dieckmann, Elaine Waldron, Carsten Korth, Edward H. Koo, Michael Heneka, Sascha Weggen, Claus U. Pietrzik

Journal:

Journal of Neurochemistry

Year:

2009

Language:

english

File:

PDF, 714 KB

english, 2009

16

Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer’s disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure

Stefanie Hahn, Tanja Brüning, Julia Ness, Eva Czirr, Sandra Baches, Harrie Gijsen, Carsten Korth, Claus U. Pietrzik, Bruno Bulic, Sascha Weggen

Journal:

Journal of Neurochemistry

Year:

2011

Language:

english

File:

PDF, 441 KB

english, 2011

17

Autoreactive-Aβ antibodies promote APP β-secretase processing

Juan Deng, Huayan Hou, Brian Giunta, Takashi Mori, Yan-Jiang Wang, Frank Fernandez, Sascha Weggen, Wataru Araki, Demian Obregon, Jun Tan

Journal:

Journal of Neurochemistry

Year:

2012

Language:

english

File:

PDF, 514 KB

english, 2012

18

Low Frequency of SV40, JC and BK Polyomavirus Sequences in Human Medulloblastomas, Meningiomas and Ependymomas

Sascha Weggen, Thomas A Bayer, Andreas von Deimling, Guido Reifenberger, Dietrich von Schweinitz, Otmar D. Wiestler, Torsten Pietsch

Journal:

Brain Pathology

Year:

2000

Language:

english

File:

PDF, 179 KB

english, 2000

19

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Weggen, Sascha, Eriksen, Jason L., Das, Pritam, Sagi, Sarah A., Wang, Rong, Pietrzik, Claus U., Findlay, Kirk A., Smith, Tawnya E., Murphy, Michael P., Bulter, Thomas

Journal:

Year:

2001

Language:

english

File:

PDF, 196 KB

english, 2001

20

Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production

Kukar, Thomas, Murphy, Michael Paul, Eriksen, Jason L, Sagi, Sarah A, Weggen, Sascha, Smith, Tawnya E, Ladd, Thomas, Khan, Murad A, Kache, Rajashaker, Beard, Jenny

Journal:

Nature Medicine

Year:

2005

Language:

english

File:

PDF, 511 KB

english, 2005

21

Identification of amplified genes from SV40 large T antigen-induced rat PNET cell lines by subtractive cDNA analysis and radiation hybrid mapping

Weggen, Sascha, Preuss, Ute, Pietsch, Torsten, Hilger, Norbert, Klawitz, Ingrid, Scheidtmann, Karl-Heinz, Wiestler, Otmar D, Bayer, Thomas A

Journal:

Year:

2001

Language:

english

File:

PDF, 220 KB

english, 2001

22

Overexpression of Human Dickkopf-1, an Antagonist of wingless/WNT Signaling, in Human Hepatoblastomas and Wilms’ Tumors

Wirths, Oliver, Waha, Anke, Weggen, Sascha, Schirmacher, Peter, Kühne, Thomas, Goodyer, Cynthia G, Albrecht, Steffen, von Schweinitz, Dietrich, Pietsch, Torsten

Journal:

Laboratory Investigation

Year:

2003

Language:

english

File:

PDF, 571 KB

english, 2003

23

SAR studies of acidic dual γ-secretase/PPARγ modulators

Martina Hieke, Julia Ness, Ramona Steri, Christine Greiner, Oliver Werz, Manfred Schubert-Zsilavecz, Sascha Weggen, Heiko Zettl

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 908 KB

english, 2011

24

LRP1 modulates APP trafficking along early compartments of the secretory pathway

Elaine Waldron, Catherine Heilig, Andrea Schweitzer, Nirupa Nadella, Sebastian Jaeger, Anne M. Martin, Sascha Weggen, Klaudia Brix, Claus U. Pietrzik

Journal:

Neurobiology of Disease

Year:

2008

Language:

english

File:

PDF, 591 KB

english, 2008

25

Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription

Elaine Waldron, Simone Isbert, Andreas Kern, Sebastian Jaeger, Anne M. Martin, Sébastien S. Hébert, Christian Behl, Sascha Weggen, Bart De Strooper, Claus U. Pietrzik

Journal:

Experimental Cell Research

Year:

2008

Language:

english

File:

PDF, 1.31 MB

english, 2008

26

Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid 42 Production by Direct Modulation of -Secretase Activity

Journal:

Journal of Biological Chemistry

Year:

2003

Language:

english

File:

PDF, 165 KB

english, 2003

27

The Metalloprotease Meprin Generates Amino Terminal-truncated Amyloid Peptide Species

Bien, J., Jefferson, T., Causevic, M., Jumpertz, T., Munter, L., Multhaup, G., Weggen, S., Becker-Pauly, C., Pietrzik, C. U.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

28

NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

Eriksen, Jason L., Sagi, Sarah A., Smith, Tawnya E., Weggen, Sascha, Das, Pritam, McLendon, D.C., Ozols, Victor V., Jessing, Kevin W., Zavitz, Kenton H., Koo, Edward H.

Journal:

Journal of Clinical Investigation

Year:

2003

Language:

english

File:

PDF, 968 KB

english, 2003

29

LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier

Thorsten Pflanzner, Maren C. Janko, Bettina André-Dohmen, Stefan Reuss, Sascha Weggen, Anton J.M. Roebroek, Christoph R.W. Kuhlmann, Claus U. Pietrzik

Journal:

Neurobiology of Aging

Year:

2011

Language:

english

File:

PDF, 1.51 MB

english, 2011

30

No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease

Antje Hillmann, Stefanie Hahn, Stephan Schilling, Torsten Hoffmann, Hans-Ulrich Demuth, Bruno Bulic, Thomas Schneider-Axmann, Thomas A. Bayer, Sascha Weggen, Oliver Wirths

Journal:

Neurobiology of Aging

Year:

2012

Language:

english

File:

PDF, 2.17 MB

english, 2012

31

NSAIDs: small molecules for prevention of Alzheimer's disease or precursors for future drug development?

Sascha Weggen, Mark Rogers, Jason Eriksen

Journal:

Trends in Pharmacological Sciences

Year:

2007

Language:

english

File:

PDF, 558 KB

english, 2007

32

Exploring the chemical space of γ-secretase modulators

Heiko Zettl, Sascha Weggen, Petra Schneider, Gisbert Schneider

Journal:

Trends in Pharmacological Sciences

Year:

2010

Language:

english

File:

PDF, 691 KB

english, 2010

33

Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells

Andreas Rennhack, Thorsten Jumpertz, Julia Ness, Sandra Baches, Claus U. Pietrzik, Sascha Weggen, Bruno Bulic

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.68 MB

english, 2012

34

O1-02-06: Genetic dissection of the PS1-ΔExon9 mutation and its attenuated response to Aβ42-lowering NSAIDs

Eva Czirr, Stefanie Leuchtenberger, Anna Schneider, Edward H. Koo, Claus U. Pietrzik, Sascha Weggen

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 73 KB

english, 2006

35

S4-04-04: γ-secretase modulators: Effects on Aβ production and therapeutic potential for familial Alzheimer's disease

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

36

The metalloprotease meprin beta generates amino-terminally truncated beta-amyloid peptide species

Jessica Bien, Tamara Jefferson, Mirsada Causevic, Thorsten Jumpertz, Lisa M. Munter, Gerd Multhaup, Sascha Weggen, Christoph Becker-Pauly, Claus Pietrzik

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 61 KB

english, 2012

37

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

Simone Isbert, Katja Wagner, Simone Eggert, Andrea Schweitzer, Gerd Multhaup, Sascha Weggen, Stefan Kins, Claus U. Pietrzik

Journal:

Cellular and Molecular Life Sciences

Year:

2012

Language:

english

File:

PDF, 984 KB

english, 2012

38

Evolution of the Molasse Basin (Germany, Switzerland)

G.H. Bachmann, M. Müller, K. Weggen

Journal:

Year:

1987

Language:

english

File:

PDF, 2.36 MB

english, 1987

39

Design, Synthesis, and Biological Evaluation of a Novel Class of γ-Secretase Modulators with PPARγ Activity

Hieke, Martina, Ness, Julia, Steri, Ramona, Dittrich, Michaela, Greiner, Christine, Werz, Oliver, Baumann, Karlheinz, Schubert-Zsilavecz, Manfred, Weggen, Sascha, Zettl, Heiko

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.75 MB

english, 2010

40

Stx5 is a novel interactor of VLDL-R to affect its intracellular trafficking and processing

Wagner, Timo, Dieckmann, Marco, Jaeger, Sebastian, Weggen, Sascha, Pietrzik, Claus U.

Journal:

Experimental Cell Research

Year:

2013

Language:

english

File:

PDF, 4.06 MB

english, 2013

41

Design and 3-D Simulations of a 10-kW/28-GHz Gyrotron With a Segmented Emitter Based on Controlled Porosity-Reservoir Cathodes

Malygin, Anton, Illy, Stefan, Pagonakis, Ioannis Gr., Piosczyk, Bernhard, Kern, Stefan, Weggen, Joerg, Thumm, Manfred, Jelonnek, John, Avramides, Konstantinos A., Ives, Robert Lawrence, Marsden, David

Journal:

IEEE Transactions on Plasma Science

Year:

2013

Language:

english

File:

PDF, 1.36 MB

english, 2013

42

P3-296 FE65 constitutes the functional link between the LDL receptor-related protein (LRP) and APP

Pietrzik, Claus U., Jaeger, Sebastian, Yoon, Il-Sang, Busse, Tracy, Weggen, Sascha, Koo, Edward H.

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 162 KB

english, 2004

43

Progranulin (GRN), a protein mutated in frontotemporal dementia with ubiquitin-positive inclusions (FTLD-U), is abundantly expressed in human gliomas

Ness, Julia S., Riemenschneider, Markus J., Baches, Sandra, Eriksen, Jason L., Pietrzik, Claus U., Reifenberger, Guido, Weggen, Sascha

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 42 KB

english, 2009

44

India USE OF ANABOLIC STEROIDS IN CHILDREN

Naumann, Eva Christine, Göring, Stefan, Ogorek, Isabella, Weggen, Sascha, Schmidt, Boris

Journal:

Year:

1984

Language:

english

File:

PDF, 177 KB

english, 1984

45

Membrane anchoring γ-secretase modulators with terpene-derived moieties

Naumann, Eva Christine, Göring, Stefan, Ogorek, Isabella, Weggen, Sascha, Schmidt, Boris

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.25 MB

english, 2013

46

P4-286

Leuchtenberger, Stefanie, Maler, Juan, Czirr, Eva, Ness, Julia, Lichtenthaler, Stefan, Wiltfang, Jens, Weggen, Sascha

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 77 KB

english, 2006

47

P4-380 Inhibitors of the RHO effector RHO-kinase (rock) modulate Aβ secretion but lack selectivity for Aβ42

Weggen, Sascha, Berdeaux, Rebecca, Kummer, Markus P., Birkenfeld, Joerg, Sagi, Sarah S., Golde, Todd E., Koo, Edward H.

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 162 KB

english, 2004

48

Aβ42-lowering compounds interfere with APP transmembrane sequence dimerization

Richter, Luise, Munter, Lisa-Marie, Ness, Julia, Hildebrand, Peter W., Joshi, Mangesh, Unterreitmeier, Stephanie, Bulic, Bruno, Beyermann, Michael, Gust, Ronald, Reif, Bernd, Weggen, Sascha, Langosch,

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 47 KB

english, 2010

49

P3-344: γ-secretase–dependent APP processing occurs either at the plasma membrane or in the endocytic compartments independent of the APP wild-type or APP Swedish variant

Pietrzik, Claus U., Jaeger, Sebastian, Wesselowski, Johanna, Cirr, Eva, Korth, Carsten, Weggen, Sascha, Koo, Edward H., Pietrzik, Klaus F.

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 58 KB

english, 2008

50

Presenilin-1 (PS1) and amyloid precursor protein (APP) mutations present in mouse models of Alzheimer's disease in their response to γ-secretase inhibitors and modulators

Lehmann, Stefanie, Bruening, Tanja, Ness, Julia, Czirr, Eva, Bulic, Bruno, Pietrzik, Claus U., Weggen, Sascha

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 64 KB

english, 2009

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